In this clip, Dr. David Sinclair and co-host Matthew LaPlante discuss Spermidine role in autophagy and it’s control of changes to the epigenome, as well as the AMPK activator Metformin and Berberine as a way to control blood sugar levels.
The Sinclair Lab website:
Nicotinamide riboside is well-tolerated in humans: Nicotinamide riboside is a sirtuin-activator:
Mice treated with nicotinamide riboside are longer-lived: Nicotinamide riboside protects mice against obesity:
An inflammatory signature is attenuated by nicotinamide riboside: Nicotinamide riboside, pterostilbene, and ALS:
Nicotinamide mononucleotide combats diabetes in mice:
Aging is slowed by nicotinamide mononucleotide:
Nicotinamide mononucleotide in prediabetic women:
NAD and cancer in mice:
Resveratrol protects mice against a high-calorie diet:
Resveratrol in patients with type 2 diabetes:
Supplementing resveratrol in metabolic syndrome patients:
Fisetin enhances longevity in mice:
Quercetin and fatty liver disease:
Dasatinib and quercetin decrease senescent cell burden:
Mice fed rapamycin late in life live longer:
Spermidine induces life extension and cardioprotection in mice:
Spermidine and older subjects with cognitive decline:
Healthspan and lifespan in mice are improved by metformin:
Metformin, age-related diseases, and mortality:
Targeting aging with metformin (TAME) trial:
Treating mice with berberine extends lifespan:
Lifespan in fruit flies is prolonged by berberine:
Berberine and metabolic disorders: C
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.
The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac – m
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