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I have already mentioned Quercetin (Q) several times in my videos. And in this video I return to this dietary supplement again for several reasons. Q is the most abundant flavonol in nature. As a dietary supplement, it is relatively inexpensive. It is especially abundant in buckwheat and onion peels, apple peels, citrus fruits, dark berries and grapes, as well as in olive oil. Since Q is a polyphenol, it works as an antioxidant in the body and acts as a scavenger of free radicals, reactive oxygen and nitrogen species responsible for oxidative chain reactions. It also acts as an anti-inflammatory, anti-cancer, and anti-allergy agent. Its beneficial effect has been proven in the slowing down of senile degeneration of nerve cells, the development of atherosclerosis and heart disease.
Q exhibits a wide range of antiviral properties. Research shows that Q can improve immune system activity and suppress viral replication. Nonofficial recommendations are to use quercetin to relieve symptoms of COVID-19 in doses of 1 to 3 g per day until disappearance of symptoms. And in this case, the quercetin supplement must be combined with the intake of vitamin C. In the normal state of the body, the beneficial effect of the Q supplement begins at 500 mg per day. And dosages above 1g per day are not recommended for long-term use. It is considered. that Q is safe to use in doses ranging from 500 mg to 1 g per day for 12 weeks, followed by a break of 1-2 weeks. Taking more than 1g of Q per day can cause symptoms such as dizziness, abdominal pain, headaches, and a tingling sensation in the skin.
Q is generally thought to be poorly absorbed from the intestines. However, recent studies have shown that humans can get a significant amount of Q from the intestines – up to 25%. The bioavailability of Q is influenced by the amount of fat in the food – the more fat, the better Q is absorbed. Therefore, it is recommended to take this dietary supplement during or immediately after the main meal. Peak plasma Q levels are reached between one and 7 hours after taking supplements. Q and its metabolites are distributed throughout the various tissues of the body. And the half-life of Q is approximately 25 hours. Moreover, in the case of a fatty diet, the half-life is significantly extended.
Recently, it has been shown that the Dasatinib (D) + Q combination can effectively remove senescent or Zombie cells in skin and reduce the concentration of pro-inflammatory cytokines in blood plasma. The D + Q combination has also been tested in humans. Only middle-aged and older men (36-40 years old) were volunteers. A total of 64 people took part in the study – 4 groups of 16 people each. The first group of participants took D – 50 mg orally together with Q – 500 mg. The second group of participants received D – 50 mg and placebo – 500 mg. At the same time, the third group of participants took Q – 500 mg together with a placebo – 50 mg. The participants in the fourth group took placebo at dosages of 500 mg and 50 mg. These participants from 4 groups took the drugs orally once a day after meals for 5 days. By the end of the trial, the first group of participants showed a very significant improvement in physical endurance compared to the rest of the groups.
Q and other flavonols only slow down the work of mitochondria and increase the concentration of ROS in cells. But if cells have an adequate supply of glucose and amino acids from blood plasma, this only temporarily slows down the production of signaling pro-inflammatory molecules (SASP) and cytokines. Because the Zombie cells may produce more mitochondria. Therefore, in order to destroy senescent or Zombie cells, it is necessary to block the production of new proteins and increase the number of mitochondria. This is naturally achieved by switching cells to autophagy mode.
So, it seems to me reasonable to practice long-term intermittent intake of a combination of Nicotinamide (NAM 0.5 – 1.0 g), Quercetin (Q 0.5 – 1.5 g), vitamin C (C 0.5 – 2.0 g) and magnesium salts (MgCl2 0.5 – 1.0 g) – 2 months with supplements and 2 weeks of a break without supplements. And to do so at least 2-4 years until a visible improvement in health will be obtained. At the same time, it is better to take Quercetin supplements once a day immediately after the main meal. It is clear that taking these supplements can be combined with intermittent fasting, taking Berberine (B 0.5 – 1.5 g) twice a day, Metformin (M 0.5 g) before bedtime, physical activity, and other dietary supplements for improving sleep (Melatonin, 5-HTP, Dramamine), supplements that are increasing testosterone levels in men (DHEA 25 – 50 mg) before exercise, vitamins – B1, B5, B6, B12, Zn, Se, as well as taking citric acid immediately after meals – (CA 1.0 – 2.0 g).